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The Research Behind Liquid Lullaby

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“Elite athletes dedicate numerous hours to daily practice, strength training, and conditioning as well as work closely with nutritionists in hopes of optimizing their athletic performance. However, very little, if any, attention is focused on an athlete’s sleeping patterns and habits. While most athletes and coaching staff may believe that sleep is an important contributing factor in sports, many do not realize that optimal or peak performance can only occur when an athlete’s sleep and sleep habits are optimal.”

- Cheri Mah, M.S., Stanford Sleep Disorders Clinic and Research Laboratory  

Athletes Are Not Getting The Sleep They Need 

As an athlete, you know that every second matters; whether it’s .10 second on the track, a last second shot on the court, five more minutes in the gym - or a few extra moments of deep sleep - every second matters.  Just like training, practice, and competition, quality sleep and recovery are essential to the success of any serious athlete; unfortunately, quality sleep is one essential component that most athletes rarely get enough of.

While there are few building blocks more important to athletic success than getting enough quality sleep, research consistently demonstrates that most athletes aren’t getting the amount of rest required.

In fact, recent research demonstrates that over 70% of athletes do not get the amount of sleep required for proper recovery and optimal performance[1]

Why Athletes Are Not Getting Enough Sleep

As an athlete, getting quality sleep is essential to your performance. Yet despite this fact, scientific studies indicate that most athletes still are not getting the proper rest they need[2],[3],[4],[5],[6].  

Research examining the sleep patterns of elite athletes during normal training (without competition) demonstrated that athletes, on the average, attempted to sleep longer than the healthy non-athletes, but took longer to fall asleep and reported lower quality of sleep when compared to non-athletes. 

The issue of sleep debt, or lack of sleep, experienced by athletes prior to competitive events they consider to be important was even more significant, with the majority of athletes reporting disturbed sleep as a result of anxiety and nervousness surrounding the competitive event as major factors contributing to poor sleep quality[7].

Why Sleep For Athletes Is So Important

As we know, sleep is vital for physical and mental function essential for peak athletic performance.  Considering athletes generate more cortisol in their bodies as a result of their training, they often find it more difficult to fall asleep[8]. This reduction in both sleep quantity and sleep quality contributes to a number of significant and undesirable effects, including issues related to learning, memory, perception of pain, immunity, and inflammation. 

Sleep deprivation can also have a negative influence on appetite, metabolism of glucose and carbohydrates, and synthesis of protein[9].  For an athlete, this can have devastating effects on athletic performance. Sleep deprivation research demonstrates that: 

Deep, quality sleep, on the other hand, promotes the release of growth hormones, which stimulate muscle repair, growth, and recovery.  Research shows that sleep deprivation inhibits the release of growth hormones, effectively limiting the amount of mental recovery and physical growth and recovery experienced during sleep.  Getting more sleep leads to better sports performance for all types of athletes, including:

What is Sleep?

Not too long ago, people believed that sleep was a time for the brain and body to shutdown in order to rest and recharge for the next day.  While the exact sleep process is still a bit of a mystery, researchers now have a better understanding of the concept of sleep and realize that neither the brain nor the body shut down during sleep; in fact, the opposite is true. 

During sleep, the brain and body actually work harder repairing and growing cells, processing important signals and information sent by specific areas of the body, removing stored toxins from the brain, and improving overall health. 

Understanding the Sleep Cycle: An In-Depth Look at the Process of Sleep

Sleep consists of two distinct states and five specific stages, non-rapid eye movement sleep (stages 1-4) and rapid eye movement sleep (stage 5).  The first four stages of sleep occur in the non-rapid eye movement, or NREM, phase and tend to gradually progress from light to deeper sleep before transitioning into rapid eye movement, or REM, sleep. 

As you progress through the phases of sleep, the body slowly lowers your heart rate, breathing rate, and body temperature.

While most of the time spent sleeping is in NREM sleep, it’s the last stages of NREM and the REM sleep stage that are the most restorative stages of sleep and essential for cell repair, cognitive processing, muscle growth and regeneration.

Most of the time sleeping, roughly 75-80%,  is spent in NREM sleep, which consists of:

Stages 3 and 4 of NREM sleep makeup over 50% of sleep time and are important for repair and rejuvenation of many cognitive and bodily functions, including cell and muscle growth and repair as well as regulating hormones responsible for stress, appetite, and growth and repair[12]

What is REM Sleep?

REM sleep makes up about 20-25%  of sleep time and typically occurs roughly 75 to 90 minutes after falling a sleep.  Because your sleep cycle repeats, you enter REM sleep several times during the night.

REM sleep is a deep sleep that is characterized by rapid eye movements, increased brain activity, and intense and vivid dreaming. REM sleep has also been shown to activate areas of the brain used for cognitive processing, storing memories, regulating hormones, organizing information and learning.  Research has also demonstrated that REM-sleep deprivation is closely associated with an inability to remember information presented before going to sleep[13].

Fortunately, research has also identified a number of all-natural ingredients that support the function of neurotransmitters associated with the sleep-wake cycle, including serotonin, gamma-aminobutyric acid (GABA), and melanin-concentrating hormone. These natural ingredients have been studied as possible sleep inducers and represent promising potential interventions[14].

Athletes, Make Your Dreams a Reality with Liquid Lullaby

As you sleep, your body heals and repairs itself. Liquid Lullaby is specifically formulated using research-based ingredients designed to help you fall asleep, stay asleep, and wake up feeling refreshed and fully recovered.

Complete with Organic CBD Isolate, MCT Oil, Grapeseed Oil, Valerian Root, Passion Flower, Lavender, and Vitamin E, our all-natural ingredients work synergistically to promote a sense of calm in the body and to help you achieve the rest, repair, and recovery your body needs. 

How Does Liquid Lullaby Promote Sleep?

Liquid Lullaby is designed for bioavailability with herbal ingredients that promote effective sleep and recovery.

Increased Bioavailability

Bioavailability is the degree and rate that a substance is absorbed and delivered to the bloodstream where it can interact with the body’s native systems.

Increased bioavailability can be tackled two ways - both theoretically (i), in terms of liver enzymatic pathways, and chemically (ii), by introducing a compound to the tincture formulation.

Liquid Lullaby maximizes bioavailability in both of these ways by:

(i) Using organic valerian root,  not only because it is reported  to offer sleep benefits, but also because it makes CBD more bioavailable. Here’s how: valerian root interacts with metabolic pathways in the liver responsible for drug metabolism - specifically, cytochrome P4503A4. CBD travels down a similar enzymatic pathway[15], and the two substances interact along this pathway. Due to the way CBD antagonizes the P450 pathway, it increases the circulation time of both CBD and valerian root extract.
(ii) There are several studies that support the use of Vitamin E TPGS to lengthen the circulation time of fatty compounds like CBD[16]. Lengthening the circulation time also increases bioavailability. Similarly, the use of MCT oil also results in increased bioavailability. MCT oil, or medium chain triglyceride oil, enhances the natural benefits of CBD by ensuring that more CBD reaches your bloodstream faster[17].

CBD, VALERIAN ROOT, PASSION FLOWER, AND LAVENDER FOR SLEEP

CBD For Sleep

CBD isolate produces calming, pain-reducing, anti-inflammatory effects by interacting with specific receptors, neurotransmitters, and proteins in the brain.  These interactions result in altered (but safe) neurotransmitter and hormone function that affect several activities related to sleep, including the sleep-wake cycle, inflammation, and pain threshold.

Benefits of CBD For Athletes

In addition to influencing the sleep-wake cycle, CBD isolate has demonstrated the ability to lessen anxiety, reduce chronic pain, improve insomnia, and increase overall sleep quality.

As CBD oil continues to support treatment of anxiety and demonstrate improved sleep quality for athletes, it also had been demonstrated to be an effective alternative to several pharmaceutical medications. These findings are supported by clinical data that demonstrates the anxiolytic, antipsychotic and neuroprotective properties of CBD oil as a safe and effective treatment for reducing anxiety and improving quality of sleep.[18],[19].

Valerian Root For Sleep

Valerian, or valerian root, is an herb used for hundreds of years as a way to treat anxiety, restlessness, insomnia, and sleep-related issues.  Valerian is also frequently combined with other herbs that have calming effects, including lavender and passionflower, as a way of treating sleep and anxiety related issues.

Considered an anxiolytic, valerian root relieves anxiety and produces calming, sedative effects by subtly increasing the levels of gamma aminobutyric acid (GABA) in the brain. GABA is a naturally occurring amino that contributes to a calming effect in the body and is considered an essential neurochemical for sleep.

Recent research demonstrated daily use of valerian for 30-days produced statistically significant effects regarding the quality of sleep experienced over the course of this study[20].

Passion Flower for Sleep

Passionflower is known to promote calm and relaxation and also provides support for mild and occasional anxiety. Passionflower also affects GABA(a) and GABA(c) subunits.  In addition, sleep quality was found to be significantly better in those supplementing with passionflower[21].Passionflower is also ingested as a way to address insomnia, pain, certain autoimmune disorders, and sleep quality[22],[23].

Lavender for Sleep

Traditionally used for calming support of the nervous system and to soothe occasional anxiety, lavender has also demonstrated to be effective in improving sleep quality and overall health[24].  Supplementing with lavender has also been associated with improving insomnia[25], produced beneficial effects on depression[26], and increased the time spent in late stages NREM and REM sleep[27]. 

YOUR STRATEGY FOR PERFORMANCE

If you are looking for a safe, effective, researched, non-habit forming sleep aid made only of organic herbal ingredients and natural oils, then look no further. Liquid Lullaby was made with you, the modern athlete, in mind

Equipped with CBD Hemp Extract, Valerian Root, Passion Flower, Lavender, and Vitamin E, Liquid Lullaby was created to help your body recharge from the demands of physical training and give you the quality sleep you need.

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SOURCES

[1] "Sleep and Athletes - Gatorade Sports Science Institute." http://www.gssiweb.org/sports-science-exchange/article/sse-167-sleep-and-athletes.

[2] "Sleep and Recovery." https://www.wm.edu/offices/sportsmedicine/_documents/sleep-manual.

[3] "Sleep in Elite Athletes and Nutritional Interventions to ... - NCBI - NIH." 3 May. 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008810/.

[4] "Sleep and Athletes - Gatorade Sports Science Institute." http://www.gssiweb.org/sports-science-exchange/article/sse-167-sleep-and-athletes.

[5] "(PDF) Sleep, Recovery, and Athletic Performance: A ... - ResearchGate." 1 Aug. 2018, https://www.researchgate.net/publication/257298429_Sleep_Recovery_and_Athletic_Performance_A_Brief_Review_and_Recommendations.

[6] "Sleep and the Elite Athlete - Gatorade Sports Science Institute." http://www.gssiweb.org/sports-science-exchange/article/sse-113-sleep-and-the-elite-athlete.

[7] "Sleep and Athletes - Gatorade Sports Science Institute." http://www.gssiweb.org/sports-science-exchange/article/sse-167-sleep-and-athletes.

[8] "Sleep of athletes – problems and possible solutions: Biological ...." https://www.tandfonline.com/doi/abs/10.1080/09291010802067023

[9] "Sleep in Elite Athletes and Nutritional Interventions to ... - NCBI - NIH." 3 May. 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008810/

[10] "The effect of partial sleep deprivation on weight-lifting ... - NCBI." https://www.ncbi.nlm.nih.gov/pubmed/8112265

[11] "Study Shows Sleep Extension Improves Athletic Performance and Mood." 29 May. 2009, https://aasm.org/study-shows-sleep-extension-improves-athletic-performance-and-mood/.

[12] "Mind, Body and Sport: Sleeping disorders | NCAA.org - The Official ...." http://www.ncaa.org/sport-science-institute/mind-body-and-sport-sleeping-disorders..

[13] "Brain Basics: Understanding Sleep | National Institute of Neurological ...." 8 Dec. 2018, https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Understanding-Sleep.

[14] "PMC - NCBI - NIH." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501138/.

[15] "Identification of cytochrome P450 enzymes responsible for ... - NCBI." 16 Jun. 2018, https://www.ncbi.nlm.nih.gov/pubmed/21704641.

[16] "The applications of Vitamin E TPGS in drug delivery - Science Direct." https://www.sciencedirect.com/science/article/pii/S0928098713000651.

[17] "Enhancing effect of medium-chain triglycerides on intestinal ... - NCBI." https://www.ncbi.nlm.nih.gov/pubmed/2746453.

[18] "Effectiveness of Cannabidiol Oil for Pediatric Anxiety and ... - NCBI." 12 Oct. 2016, https://www.ncbi.nlm.nih.gov/pubmed/27768570.

[19] "Translational Investigation of the Therapeutic Potential of ... - NCBI." 21 Sep. 2018, https://www.ncbi.nlm.nih.gov/pubmed/30298064

[20] "A Systematic Review and Meta-analysis on the Effect of Herbal ... - NCBI." 31 Aug. 2018, https://www.ncbi.nlm.nih.gov/pubmed/30202758

[21] "Passionflower: A review of research and clinical indications - Gaia Herbs." https://www.gaiaherbs.com/uploads/A_Research_Review_of_Passionflower-1371567390.pdf

[22] "Modulation of the γ-aminobutyric acid (GABA) system by ... - NCBI." https://www.ncbi.nlm.nih.gov/pubmed/21089181

[23] "Passionflower: Uses, Side Effects, Interactions, Dosage, and ... - WebMD." https://www.webmd.com/vitamins/ai/ingredientmono-871/passionflower

[24] "Effect of aromatherapy on the quality of sleep in ischemic heart ... - NCBI." https://www.ncbi.nlm.nih.gov/pubmed/22049287.  .

[25] "A single-blinded, randomized pilot study evaluating the aroma ... - NCBI." https://www.ncbi.nlm.nih.gov/pubmed/16131287

[26] "[Effects of lavender aromatherapy on insomnia and depression ... - NCBI." https://www.ncbi.nlm.nih.gov/pubmed/16520572

[27] "An olfactory stimulus modifies nighttime sleep in young men ... - NCBI." https://www.ncbi.nlm.nih.gov/pubmed/16298774